Melanya A Samvelyan
Yerevan State University, Armenia
Title: The synthesis of potentially bioactive new compounds in the field of 3,4-disubstituted -5-mercapto -1, 2,4-tiazoles
Biography
Biography: Melanya A Samvelyan
Abstract
Heterocyclic compounds are attractive objects for chemists and pharmacologists. Particularly derivatives of triazoles acted as active pharmaceutical agents and used as antitumor, anticonvulsant, antifungal, insecticidal, anticancer and antidepressant. It's known that the triazole's ring is enough stability and decomposes in harsh environments, and it is the main thing that the triazole ring containing drugs generally not confirmed destruction during of the time metabolism. For the enhancement of activity derivatives of 1,2,4-triazoles, we imported bioactive fragments, such as morpholine, secondary amines, pyridine and other fragments which are already part of many medications. We was carried out number of methods for the synthesis of new derivatives 1,2,4-triazoles, studied the reactions of Mannich, Michael's and reactions of substitution mercapto groups for our systems. Below there is a graphical scheme of our research. We have also shown that the mercapto triazoles are antioxidants and anti-radiation good agents. So in this work we synthesized bis-heterocyclic compounds, where the triazole ring is aligned with the mercapto triazoles and mercapto oxadiazoles. We are sure that the synthesized compounds are bioactive.