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Bruno J Gonzalez

Normandy University/Inserm NeoVasc, Rouen, France

Biography

Bruno J Gonzalez is PhD Researcher at the National Institute for Medical Research and Head of the NeoVasc Laboratory “Microvascular Endothelium and Neonatal Brain Lesions”, Normandy University, France. He developed a research program on pathologic neurodevelopment in preterm and term neonates with a particular attention to neurovascular defects. His working hypotheses are (1) microvessels contribute to injurious mechanisms with age-dependent specificities, (2) microvessels are targets for therapeutic actions, and (3) brain microvessels release factors with biomarker potential. Focusing on NMDA receptors, his objectives consist of molecular and functional characterizations of endothelial and neuronal interactions (GABA interneurons) and of deleterious/side effects of drugs (alcohol, anesthetics).

Abstract

Abstract : Blockade of the NMDA receptor in developing cortex induces autophagy-mediated death of migrating cortical GABAergic interneurons: an ex in vivo and in vivo study in GAD67-GFP mice